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Research
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Laboratory Mission Statement:
The Rimm Laboratory spans a range of topics in three main areas including: 1) basic issues; including regulation of cell adhesion and growth factor signaling, 2) translation issues; including tissue biomarkers, circulating cancer cells, tissue microarrays and digital pathology, and 3) clinical issues: including advanced objective diagnostics using novel information gathering technologies.
Studies include:
- Translational studies using tissue microarray technology and digital pathology algorithms (AQUA) to apply basic, rigorous molecular technology to diagnostic problems in pathology and cytopathology toward the goal of development of new predictive and prognostic tissue biomarkers.
- Studies of the organization and regulation of the biochemical interactions occurring at the cytoplasmic face of the cadherin-based adhesion complex involving signal transduction and the cytoskeleton
- The examination of genetic alterations or changes in expression levels of components of the cadherin cascade (Ecadherin a-catenin and b-catenin) or associated regulatory proteins (Met, HGF/SF receptor) in epithelial tumors and metastases.
- Analysis of micro-metastasis and circulating cancer cells in the peripheral blood for both diagnostic and prognostic applications.
- Use of spectral analysis for tumor diagnosis and classification in surgical pathology and cytopathology
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